Schematic showing the position of the locus coeruleus at 6dpf based on the 3D anatomical segmentation used by the Zebrafish Brain Browser by Gupta et al., 2018.
Description
The locus coeruleus is one of the main source of noradrenaline projections into the forebrain. The neurotransmitter noradrenaline is important modulators of sleep/wakefulness, learning & memory, attention and reward (Farrar et al., 2018).
The locus coeruleus sends long-range projections to the olfactory bulb, subpallium, pretectum, posterior tuberculum, hypothalamus, optic tectum, and to hindbrain and spinal cord (Tay et al., 2011).
Ontology
is part of: hindbrain, medulla oblongata, noradrenergic system.
has parts:
Transgenic Lines that label this brain region
The y405-Gal4 line was used to anatomically segment the locus coeruleus by the Zebrafish Brain Browser.
Tabor, K.M., Marquart, G.D., Hurt, C., Smith, T.S., Geoca, A.K., Bhandiwad, A.A., Subedi, A., Sinclair, J.L., Rose, H.M., Polys, N.F., Burgess, H.A. (2019) Brain-wide cellular resolution imaging of Cre transgenic zebrafish lines for functional circuit-mapping. eLife 2019;8:e42687 DOI: 10.7554/eLife.42687
Antibodies that label this brain region
Key Publications
Ma, P.M. (1994)
Catecholaminergic systems in the zebrafish. II. Projection pathways and pattern of termination of the locus coeruleus.
The Journal of comparative neurology. 344:256-269.
Kastenhuber E., Kratochwil C. F., Ryu S., Schweitzer J., Driever W. (2010).
Genetic dissection of dopaminergic and noradrenergic contributions to catecholaminergic tracts in early larval zebrafish.
J. Comp. Neurol. 518, 439–458. doi: 10.1002/cne.22214
Farrar, M.J., Kolkman, K.E., Fetcho, J.R. (2018)
Features of the structure, development and activity of the Zebrafish Noradrenergic System explored in new CRISPR transgenic lines.
The Journal of comparative neurology. 526(15):2493-2508.
Tay, T. L., Ronneberger, O., Ryu, S., Nitschke, R., & Driever, W. (2011).
Comprehensive catecholaminergic projectome analysis reveals single-neuron integration of zebrafish ascending and descending dopaminergic systems.
Nature Communications, 2(1), 171–112.
McLean, D. L., & Fetcho, J. R. (2004).
Ontogeny and innervation patterns of dopaminergic, noradrenergic, and serotonergic neurons in larval zeb- rafish.
The Journal of Comparative Neurology, 480(1), 38–56.