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Morphogenesis Lab


Unravelling the principles of multicellular morphogenesis

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Morphogenesis Lab


Unravelling the principles of multicellular morphogenesis

 

We are a developmental biology lab at UCL, within the Department of Cell and Developmental Biology (CDB). We are affiliated with COCO (Centre for Organelles to Cells to Organisms) and IPLS (Institute for the Physics of Life Sciences).

Our goal is to unravel the principles of multicellular morphogenesis using a combination of tools from experimental embryology, biophysics, and molecular biology. We work with different models, including zebrafish, chicken, and in vitro systems derived from human iPS cells.

We’re drawn to processes that happen at the tissue scale, yet we strive to link different levels of organizations, from molecules to organs. We believe that cells, more than simple “bags of RNA”, are the dynamic organizing centers of tissue morphogenesis.

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People


People


Alessandro Mongera

Principal Investigator

I'm a developmental biologist fascinated by the causes and constraints of multicellular morphogenesis. After earning my Master's in Evolutionary Biology from the University of Padua, Italy, I pursued my PhD at the Max Planck Institute for Developmental Biology in Germany under the guidance of Dr. Christiane Nüsslein-Volhard. Following that, I conducted postdoctoral research first as an EMBO Postdoctoral Fellow at the University of California, Santa Barbara, under the mentorship of Otger Campàs, and later at Harvard Medical School under the mentorship of Olivier Pourquié. In April 2023, I established the Multicellular Morphogenesis Lab at the UCL Department of Cell and Developmental Biology.


Current Lab Members

  • LiDo PhD Student
    I’m a PhD student in the BBSRC-funded LIDo programme, working in collaboration with the Logan Lab, King's College London. My research delves into the mechanical and metabolic control of chick limb morphogenesis, employing techniques such as in ovo sub-blastodermal injections of metabolic inhibitors and in situ hybridization. Beyond academia, I find joy in artistic pursuits, gaming, and story writing.

  • MRes student
    I graduated from the University of Edinburgh with a bachelor's in Anatomy and Development and am currently doing my Master's by Research on the topic of Stem Cells and Developmental Biology. I am very interested in the fields of mechanobiology and tissue engineering, and more specifically in the effects of mechanical forces on cell behaviour during early zebrafish development.  I'm excited to be working on a project investigating the effects of mechanical perturbations on developmental tempo. In my free time, I like to cook, watch movies, and I enjoy going on hikes.

  • MRes student
    My interest in developmental biology began during my BSc Biochemistry degree from the University of Portsmouth. Following my passion, I am now pursuing a master's degree at UCL. I am particularly enthusiastic about understanding how the cellular microenvironment influences cell fate decisions and differentiation during development. Currently, my research project involves working with chicken embryos, where I am investigating cell motility in the presomitic mesoderm and its contribution to elongation and somite formation. Moreover, I am very passionate about dancing. In my spare time, I like to attend dance classes and join shows on occasions.

Aisha Samee
Undergraduate research assistant

Thavisha Jayawardana
Undergraduate student 


Former Lab Members

Yu Hong Law
Undergraduate student

Jiarui Miao
Undergraduate student

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Publications


Publications


Peer Reviewed

Miao Y, Djeffal Y, De Simone A, Zhu K, Lee JG, Lu Z, Silberfeld A, Rao J, Tarazona OA, Mongera A, Rigoni P, Diaz-Cuadros M, Song LMS, Di Talia S, Pourquié O.
Reconstruction and deconstruction of human somitogenesis in vitro.
Nature. 2023 Feb;614(7948):500-508. doi: 10.1038/s41586-022-05655-4. Epub 2022 Dec 21.
PMID: 36543321; PMCID: PMC10018515.

Mongera A*, Pochitaloff M*, Gustafson HJ, Stooke-Vaughan GA, Rowghanian P, Kim S, Campàs O.
Mechanics of the cellular microenvironment as probed by cells in vivo during zebrafish presomitic mesoderm differentiation.
Nat Mater. 2023 Jan;22(1):135-143. doi: 10.1038/s41563-022-01433-9. Epub 2022 Dec 28.
PMID: 36577855; PMCID: PMC9812792.

Mongera A, Rowghanian P, Gustafson HJ, Shelton E, Kealhofer DA, Carn EK, Serwane F, Lucio AA, Giammona J, Campàs O.
A fluid-to-solid jamming transition underlies vertebrate body axis elongation.
Nature. 2018 Sep;561(7723):401-405. doi: 10.1038/s41586-018-0479-2. Epub 2018 Sep 5.
PMID: 30185907; PMCID:PMC6148385.

Lucio AA, Mongera A, Shelton E, Chen R, Doyle AM, Campàs O.
Spatiotemporal variation of endogenous cell-generated stresses within 3D multicellular spheroids.
Sci Rep. 2017 Sep 20;7(1):12022. doi: 10.1038/s41598-017-12363-x.
PMID: 28931891; PMCID: PMC5607343.

Serwane F, Mongera A, Rowghanian P, Kealhofer DA, Lucio AA, Hockenbery ZM, Campàs O.
In vivo quantification of spatially varying mechanical properties in developing tissues.
Nat Methods. 2017 Feb;14(2):181-186. doi: 10.1038/nmeth.4101. Epub 2016 Dec 5.
PMID: 27918540; PMCID: PMC5524219.


Reviews

Mongera A*, Michaut A*, Guillot C, Xiong F, Pourquié O.
Mechanics of Anteroposterior Axis Formation in Vertebrates.
Annu Rev Cell Dev Biol. 2019 Oct 6;35:259-283. doi: 10.1146/annurev-cellbio-100818-125436. Epub 2019 Aug 14.
PMID: 31412208; PMCID: PMC7394480.


Preprints

Michaut A*, Mongera A*, Gupta A, Serra M, Rigoni P, Lee JG, Duarte F, Hall AR, Mahadevan L, Guevorkian K, Pourquié O,
Activity-driven extracellular volume expansion drives vertebrate axis elongation.
BioRxiv 2022 June doi: https://doi.org/10.1101/2022.06.27.497799.

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Contact


Contact


Contact Us

 

We are proudly located on the second floor (the ‘Embryology floor’) of the Anatomy Building at University College London. This is where notable figures like evolutionary embryologist Gavin de Beer, cell biologist Michael Abercrombie , neurophysiologist J.Z. Young, and developmental biologist Lewis Wolpert once had their own laboratories.

We share this space with fantastic colleagues working across biological scales, from cell signaling to animal development, from stem cell biology to evolutionary morphology. You can explore more about them here.

Multicellular Morphogenesis Lab
Department of Cell & Developmental Biology
University College London
Anatomy Building, Gower Street
London
WC1E 6BT

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Join Us


Join Us


Join Us

Whether you are looking for a summer internship, a master project, a PhD, or a postdoc, we are always looking for motivated people to join the lab. If interested in our science, please understand that we prioritize qualities like good citizenship, enthusiasm, and a spirit of sharing.

To start a conversation, contact us at a.mongera@ucl.ac.uk