About sst1.1
somatostatin 1
sst1 is orthologous to human SST, somatostatin . This gene encodes a peptide hormone that modulates neurotransmission. Zebrafish have 6 different somatostatin genes.
Expression pattern
sst1.1 is expressed in the habenula, neurosecretary pre-optic area NPO, subpallium, preoptic area, posterior tuberculum, ventral thalamus, hypothalamus, interpeduncular nucleus, medulla oblongata.
Flythrough movie of a 6dpf larvae labelled using fluorescent in-situ hybridisation using a probe against sst1.1. This probe labels neurons that secrete the peptide hormone somatostatin.
Montage of slices through the brain of a 6dpf zebrafish larvae labelled using fluorescent in-situ hybridisation using a probe against sst1.1.
Z projection of a 6dpf larvae labelled using fluorescent in-situ hybridisation using a probe against sst1.1.
6dpf brain of a larval zebrafish labeled with a probe against sst1.1 . this stack was morphed to ZBB. This screenshot shows the sst1.1 stack and a HuC/D antibody labelling uploaded to ZBB and viewed using their online browser. If you would like to look at this data using ZBB please download the .png file using the link below and upload it to ZBB using the Lines> Custom>Load option.
Selected images
All imaging by Chintan Trivedi on a lightsheet microscope.
External links
Addgene probe link
Download the sst1.1 .png file to view the data using Zebrafish Brain Browser
FISH Protocol
Key Publications
Devos, N., Deflorian, G., Biemar, F., Bortolussi, M., Martial, J.A., Peers, B., and Argenton, F. (2002)
Differential expression of two somatostatin genes during zebrafish embryonic development.
Mechanisms of Development. 115(1-2):133-137.
deCarvalho, T.N., Subedi, A., Rock, J., Harfe, B.D., Thisse, C., Thisse, B., Halpern, M.E., Hong, E. (2014) Neurotransmitter map of the asymmetric dorsal habenular nuclei of zebrafish.
Genesis (New York, N.Y. : 2000). 52(6):636-55.
Liu, Y., Lu, D., Zhang, Y., Li, S., Liu, X., and Lin, H. (2010)
The evolution of somatostatin in vertebrates.
Gene. 463(1-2):21-28.
Herget, U., Wolf, A., Wullimann, M.F., and Ryu, S. (2014)
Molecular neuroanatomy and chemoarchitecture of the neurosecretory preoptic-hypothalamic area in zebrafish larvae.
The Journal of comparative neurology. 522(7):1542-64.
Herget, U., Ryu, S. (2015)
Coexpression analysis of nine neuropeptides in the neurosecretory preoptic area of larval zebrafish.
Frontiers in Neuroanatomy. 9:2.