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Bianco Lab


understanding the logic of brain circuits that control behaviour

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Bianco Lab


understanding the logic of brain circuits that control behaviour

Research

Our aim is to understand fundamental aspects of the structure and operation of the neural circuits that process sensory information to control animal behaviour.

We work with larval zebrafish – a vertebrate model that has a tiny, optically transparent brain – enabling us to use advanced light microscopy techniques to monitor neural activity during behaviour.

2-photon and light sheet microscopes allow us to record activity at single cell resolution throughout the brain of transgenic fish expressing genetically-encoded calcium indicators, which report neural activity with changes in fluorescence.

Our focus is on brain circuits that process visual stimuli (for example resembling predators or prey) to control adaptive behavioural responses (such as escape or hunting). We build virtual reality environments for zebrafish and examine neural activity underlying visual perception and the generation of locomotor programmes whilst the animal responds to naturalistic visual stimuli.

 
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News


News


BIANCO LAB NEWS

 
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People


People


PEOPLE

Former members:

Charlotte Leigh, iBSc student

Andrien Rajakumar, iBSc student

Yue Wu, MSc student

Niloy Rahmen, iBSc student

Mingxu Shan, MSc student

Sam Jackson, iBSc student

 
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Join us/Contact


Join us/Contact


Join us

We enthusiastically encourage applications from prospective students or postdocs.

Techniques that we specialise in include 2-photon and light sheet microscopy, analysis of population dynamics in neural circuits, design of novel behavioural assays and development of optogenetic approaches for precise control of neural activity in vivo.

Our lab is part of several excellent graduate programmes:

Wellcome Trust/MRC 4yr PhD in Neuroscience
UCL-Birkbeck MRC Doctoral Training Programme
• London Interdisciplinary Doctoral Programme

 

Contact Us

Please contact Isaac Bianco for more information.
For directions to the lab, click here.

 
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Publications


Publications


Publications

Schoppik D, Bianco IH, Prober DA, Douglass AD, Robson DN, Li JMB, Greenwood JSF, Soucy E, Engert F, Schier AF. Gaze-stabilizing central vestibular neurons project asymmetrically to extraocular motoneuron pools. J Neurosci. (2017) pii: 1711-17. doi: 10.1523/JNEUROSCI.1711-17.2017

Wolf S, Dubreuil AM, Bertoni T, Böhm UL, Bormuth V, Candelier R, Karpenko S, Hildebrand DGC, Bianco IH, Monasson R, Debrégeas G. Sensorimotor computation underlying phototaxis in zebrafish. Nat Commun. (2017) 8:651. doi: 10.1038/s41467-017-00310-3.

Hildebrand DGC, Cicconet M, Torres RM, Choi W, Quan TM, Moon J, Wetzel AW, Scott Champion A, Graham BJ, Randlett O, Plummer GS, Portugues R, Bianco IH, Saalfeld S, Baden AD, Lillaney K, Burns R, Vogelstein JT, Schier AF, Lee WA, Jeong WK, Lichtman JW, Engert F. Whole-brain serial-section electron microscopy in larval zebrafish. Nature (2017). doi:10.1038/nature22356

Zou M, Friedrich RW, Bianco IH. Targeted Electroporation in Embryonic, Larval, and Adult Zebrafish. Methods Mol Biol (2016). 1451:259-69.

Bianco IH and Engert F. Visuomotor transformations underlying hunting behavior in zebrafish. Current Biology (2015). 25:1-16.

Hüsken U, Stickney HL, Roussigne M, Beretta CA, Brinkmann I, Young RM, Bianco IH, Tsalavouta M, Zigman M, Hawkins TA, Wen L, Zhang B, Blader P, Lin S, Wilson SW, Carl M. Tcf7l2-dependent asymmetries in Wnt signalling mediate the left-right asymmetric differentiation of habenular neurons. Current Biology (2014). 24:2217-27.

Concha MC, Bianco IH, Wilson SW. Encoding asymmetry within neural circuits. Nature Reviews Neuroscience. (2012). 13:832-43.

Bianco IH, Ma L-H, Schoppik D, Robson DN, Orger MB, Beck JC, Li JM, Schier AF, Engert F, Baker R. The tangential nucleus controls a gravito-inertial vestibulo-ocular reflex. Current Biology (2012). 22:1285-95.

Bianco IH, Kampff AR, Engert F. Prey capture behavior evoked by simple visual stimuli in larval zebrafish. Front. Syst. Neurosci. (2011). 5:101.

Tawk M, Bianco IH, Clarke JD. Focal electroporation in zebrafish embryos and larvae. Methods Mol Biol. (2009). 546:145-51.

Roussigné M, Bianco IH, Wilson SW, Blader P. Nodal signalling imposes left-right asymmetry upon neurogenesis in the habenular nuclei. Development. (2009). 136:1549-57.

Bianco IH, Wilson SW. The habenular nuclei: a conserved asymmetric relay station in the vertebrate brain. Philos Trans R Soc Lond B Biol Sci. (2009). 364:1005-20.

Bianco IH, Carl M, Russell C, Clarke JD, Wilson SW. Brain asymmetry is encoded at the level of axon terminal morphology. Neural Dev. (2008). 3:9.

Carl M, Bianco IH, Bajoghli B, Aghaallaei N, Czerny T, Wilson SW. Wnt/Axin1/beta-catenin signaling regulates asymmetric nodal activation, elaboration, and concordance of CNS asymmetries. Neuron. (2007). 55:393-405.

Barth KA, Miklosi A, Watkins J, Bianco IH, Wilson SW, Andrew RJ. fsi zebrafish show concordant reversal of laterality of viscera, neuroanatomy, and a subset of behavioral responses. Curr Biol. (2005). 15:844-50.

Aizawa H, Bianco IH, Hamaoka T, Miyashita T, Uemura O, Concha ML, Russell C, Wilson SW, Okamoto H. Laterotopic representation of left-right information onto the dorso-ventral axis of a zebrafish midbrain target nucleus. Curr Biol. (2005). 15:238-43.

Mo E, Amin H, Bianco IH, Garthwaite J. Kinetics of a cellular nitric oxide/cGMP/phosphodiesterase-5 pathway. J Biol Chem. (2004). 279:26149-58.

 
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Funding


Funding


Our work is generously supported by the following funders: