Zebrafish dopaminergic system
Dopamine is a monoamine neurotransmitter, part of the catecholamine family of monoamines, which also includes noradrenaline and adrenaline.
Dopaminergic (DA) neurons are found throughout the forebrain in distinct clusters, each with characteristic local and/or long-range projections. There are no DA neurons in the midbrain or hindbrain of zebrafish. The catecholaminergic cells in the hindbrain are noradrenergic (NA) neurons located in the locus coeruleus and the medulla oblongata. DA and NA neurons make up some of the major long-range projection systems in the vertebrate brain (Tay et al., 2011).
In addition to its role as a neurotransmitter, dopamine also functions as a hormone released from the hypophysis (pituitary gland). Through its neurotransmitter and hormonal functions dopamine controls a wide range of behaviours in the brain of both vertebrates and invertebrates. These functions include cognition, voluntary movement, motivation, reward pathways, mood, attention and learning (Schweitzer et al., 2011).
The majority of DA neuronal clusters are located in the diencephalon of the zebrafish brain. These diencephalic clusters have been assigned numbers DC1-DC7 based on their location along the anterior-posterior axis.
In the telencephalon there are two bilateral clusters of DA cells in the olfactory bulb (OB) and the subpallium (SP).
DA neurons are also found in the amacrine cell layer of the retina, the anterior and posterior parts of the parvocellular preoptic area and the periventricular pretectum.
This tutorial was written by Andy Simmonds. All images are modified from Kastenhuber et al., 2010. We thank Wolfgang Driever for supplying us with these beautiful images.
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