Müller glia

Müller glia (MG) cells stretch though all of retina layers, interacting with each of the cell types (Wang et al., 2017), maintaining and supporting the retina (Reichenbach and Bringmann, 2013). MG have a critical part in ageing, stress and disease, as the cells’ response to neuronal damage is inflammation, called gliosis, which contributes towards neurodegeneration (Bringmann and Wiedemann, 2012). Unlike in mammals retina (Salman, McClements and MacLaren, 2021)., MG in zebrafish retina can regenerate the retina (Martins et al., 2022). This regenerative ability is of particular importance as ageing hallmarks of the retina include neuronal loss, tissue thinning and ultimately vision loss (Eriksson and Alm, 2009; Salvi, Akhtar and Currie, 2006).

Antibodies that label the Müller glia

Featured

Glutamine Synthetase (GS)

Glutamine Synthetase (GS)

Section of killifish retina anti-Rblp1 in green and DAPI in blue

Retinaldehyde binding protein 1 (Rblp1)

Vimentin

Yes associated protein (YAP)

References

Bringmann A, Wiedemann P. 2012. Müller glial cells in retinal disease. Ophthalmologica. 227:1-19.

Eriksson U, Alm A. 2009. Macular thickness decreases with age in normal eyes: a study on the macular thickness map protocol in the Stratus OCT. British Journal of Ophthalmology. 93:1448-1452.

Martins RR, Zamzam M, Moosajee M, Thummel R, Henriques CM, MacDonald RB. 2022. Müller Glia maintain their regenerative potential despite degeneration in the aged zebrafish retina. Aging Cell. 21:1-20.

Reichenbach A, Bringmann A. 2013. New functions of Müller cells. Glia. 61:651-678.

Salman A, McClements ME, MacLaren RE. 2021. Insights on the regeneration potential of Müller glia in the mammalian retina. Cells. 10:1-12.

Salvi SM, Akhtar S, Currie Z. 2006. Ageing changes in the eye. Postgraduate Medical Journal. 82:581-587.

Wang J, O’Sullivan ML, Mukherjee D, Puñal VM, Farsiu S, Kay JN. 2017. Anatomy and spatial organization of Müller glia in mouse retina. Journal of Comparative Neurology. 525:1759-1777.