Sabine Reichert and Jason Rihel publish new paper in Neuron on the role of Galanin in sleep.

Sabine Reichert and Jason Rihel publish new paper in Neuron on the role of Galanin in sleep.

Read the press release here

“The intensity of brain activity during the day, notwithstanding how long we've been awake, appears to increase our need for sleep, according to a new UCL study in zebrafish.

The research, published in Neuron, found a gene that responds to brain activity in order to coordinate the need for sleep. It helps shed new light on how sleep is regulated in the brain.”

Full article below.

Sabine Reichert, Oriol Pavón Arocas, Jason Rihel
The Neuropeptide Galanin Is Required for Homeostatic Rebound Sleep following Increased Neuronal Activity
Neuron (2019) DOI:https://doi.org/10.1016/j.neuron.2019.08.010

Congratulations Sabine and Jason!

We are hiring!

We are hiring!

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Are you a talented and enthusiastic post-doc looking to work on nervous system development and function in zebrafish?  If so, we are currently recruiting to our exciting and collaborative research team.

Our group uses zebrafish to investigate brain and eye development, from early morphogenesis to circuit formation and behaviour (http://zebrafishucl.org/wilson-lab#wilson-lab/about-us ).  One focus for our research is upon left-right asymmetry; the developmental and genetic mechanisms by which asymmetries are established and encoded in circuits and how such asymmetries impact behaviour.

The zebrafish community and UCL more widely offers a vibrant and very collaborative research environment, state-of-the art facilities and close proximity to many other research institutes of excellence.

Here is the link to the job description and application process:

https://atsv7.wcn.co.uk/search_engine/jobs.cgi?SID=amNvZGU9MTgxOTc4MSZ2dF90ZW1wbGF0ZT05NjUmb3duZXI9NTA0MTE3OCZvd25lcnR5cGU9ZmFpciZicmFuZF9pZD0wJnZhY194dHJhNTA0MTE3OC41MF81MDQxMTc4PTkyNzg2JnZhY3R5cGU9MTI3NiZsb2NhdGlvbl9jb2RlPTE1OTYxJnBvc3RpbmdfY29kZT0yMjQ=

We are also recruiting one or maybe two technical positions to our group.

Ingrid Lekk's new paper on Sox1a and the parapineal published in eLife

Ingrid Lekk's new paper on Sox1a and the parapineal published in eLife

The Wilson labs latest paper on one of our favourite structures the parapineal has just been published in eLife. In this work , Ingrid shows that normal function of Sox1a is required for the parapineal to impart left-sided molecular character and efferent connectivity to habenula neurons, despite not being required for the specification and migration of the parapineal itself.

Read this open access paper in eLife:

Sox1a mediates the ability of the parapineal to impart habenular left-right asymmetry. eLife 2019;8:e47376 DOI: 10.7554/eLife.47376

or check out the publication summary.

Authors :Ingrid Lekk, Véronique Duboc, Ana Faro, Stephanos Nicolaou, Patrick Blader, Stephen W Wilson

The parapineal emerges from the pineal during zebrafish embryogenesis, as shown by confocal images of a transgenic line with GFP in the pineal complex (top pictures). The pineal complex lies at the midline of the epithalamus, flanked by left (green on the scheme) and right (magenta on the scheme) habenulae. The habenulae are innervated by the parapineal and themselves send neuronal projections to the midbrain interpeduncular nucleus (IPN). The side of the parapineal, on the left in wild-type (wt), determines which habenula acquires a left-type identity projecting to the dorsal part of the IPN (dIPN).

The parapineal emerges from the pineal during zebrafish embryogenesis, as shown by confocal images of a transgenic line with GFP in the pineal complex (top pictures). The pineal complex lies at the midline of the epithalamus, flanked by left (green on the scheme) and right (magenta on the scheme) habenulae. The habenulae are innervated by the parapineal and themselves send neuronal projections to the midbrain interpeduncular nucleus (IPN). The side of the parapineal, on the left in wild-type (wt), determines which habenula acquires a left-type identity projecting to the dorsal part of the IPN (dIPN).

Congratulations to Ingrid!

Technician position opening

Technician position opening

The MacDonald Lab joining the Institute of Opthalmology will be recruiting for a technician. Advert coming soon…watch this space!

Ryan MacDonald to join UCL Institute of Opthalmology.

Ryan MacDonald to join UCL Institute of Opthalmology.

Dr Ryan McDonald, a BBSRC David Phillips Fellow is joining the Institute of Ophthalmology, UCL from the University of Sheffield where he is JG Graves Medical Research Fellow in department of Infection, Immunity and Cardiovascular Disease.

Ryan’s lab will study the role of cell adhesion molecules in glial morphogenesis using the zebrafish retina as a model system. CLick here to see the UCL press release and read more about the MacDonald Lab research.

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Dr Renato!

Dr Renato!

Congratulations to Renato on getting his doctorate.

Fellowship Award to Asaph!

Fellowship Award to Asaph!

Congratulations to Asaph who was recently awarded a prestigious BBSRC Discovery Fellowship. It is all the more impressive because this is the first Discovery Fellowship ever awarded to any UCL researcher!

The award will allow Asaph to combine cellular resolution whole-brain functional imaging in larval zebrafish and modern machine learning techniques, to study how the brain transforms visual input to behaviour.

https://www.ucl.ac.uk/biosciences/biosciences-news-publication/2018-2019/discovery-fellowship-asaph-zylbertal

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Pedro's viva!

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We’re all extremely proud of Pedro who by all accounts nailed his viva today [err, actually yesterday - ed]! First Bianco lab PhD… Celebrations much deserved!

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2018 Project Students

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The Bianco lab are pleased to welcome Kristie, Nicole and Adam (from left to right), who will be doing their research projects with us this year.

ZENITH training programme is funded!

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The Bianco lab are really excited to be part of a consortium that has been awarded funding from the EC Horizon 2020 ITN scheme. Our ZENITH (ZEbrafish Neuroscience Interdisciplinary Training Hub) programme will be training 15 graduate students in interdisciplinary systems neuroscience projects investigating sensorimotor processing using larval zebrafish.

Congratulations to everyone in the consortium and especially Claire Wyart and Alexandra Chukas for coordinating it all.

Thesis hand-in!

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Congratulations to Pedro, who handed in his PhD thesis today!

FENS 2018

Joanna attends FENS 2018

Anna Krasnow's paper shortlisted for the MS Society Awards 2018

Anna Krasnow's paper shortlisted for the MS Society Awards 2018

The paper entitled: "Regulation of developing myelin sheath elongation by oligodendrocyte calcium transients in vivo"  and published in Nature Neuroscience in 2018 by Anna Krasnow, David Attwell and colleagues, has been shortlisted as a finalist for the MS Society Awards 2018

'In Multiple Sclerosis(MS), the myelin coating that protects our nerves is attacked by the immune system. To stop MS, we need to understand more about how myelin is made and repaired.

The researchers showed that calcium controls the development of myelin in zebrafish. High levels of calcium promoted myelin development whilst low levels prevented myelin development.
These results support further research into myelin development and repair in MS.’

Welcome Charlie!

Welcome to Charlie, a Wellcome Trust 4 Yr PhD student who is rotating in the lab. And also Happy Birthday to Megan!

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