Glial fibrillary acidic protein (Gfap)

Glial fibrillary acidic protein (Gfap)

ABOUT THIS ANTIBODY

Anti-Gfap labels gliosis

Glial fibrillary acidic protein (Gfap) is an intermediate filament protein found in Müller glia and is upregulated under retinal stress. It has been found to label retinal gliosis in zebrafish (Dhakal et al., 2021). Gfap antibody showed a strong staining along the Müller glia in the killifish.

Rabbit polyclonal anti-Gfap (Proteintech, Cat#16825-1-AP, dilution 1:100)

image

by Eva-Maria Breitenbach

Section of 2 mpf female killifish sodium citrate antigen retrieval anti-Gfap (green) and DAPI (blue)

PS = photoreceptors, ONL = outer nuclear layer, OPL = outer plexiform layer, INL = inner nuclear layer, IPL = inner plexiform layer, GCL = ganglion cell layer

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labels these retinal cell types

Gliosis

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key publications

Dhakal S, Rotem-Bamberger S, Sejd JR, Sebbagh M, Ronin N, Frey RA, Beitsch M, Batty M, Taler K, Blackerby JF and Inbal A. 2021. Selective requirements for vascular endothelial cells and circulating factors in the regulation of retinal neurogenesis. Frontiers in Cell and Developmental Biology. 9:1-23.